Makbule Eren

• Hacettepe Üniversitesi Tığ Fakültesi 1997 
• Hacettepe Üniversitesi, Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı (2002) 
• Hacettepe Üniversitesi, Tıp Fakültesi İhsan Doğramacı Çocuk Hastanesi (2004)

• Hacettepe Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları AD., Ankara (1997-2002)
• Hacettepe Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları AD, Gastroenteroloji, Hepatoloji ve Beslenme Ünitesi, Ankara (2002-2004)
• Başkent Üniversitesi Tıp Fakültesi, Uygulama Ve Araştırma Hastanesi, Alanya (2004-2006)
• Başkent Üniversitesi Tıp Fakültesi, Uygulama Ve Araştırma Hastanesi, Alanya (2006)
• Eskisehir Osmangazi Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı. Çocuk Gastroenteroloji ve Hepatoloji Bilim Dalı (2006-2007)
• Eskisehir Osmangazi Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı. Çocuk Gastroenteroloji ve Hepatoloji Bilim Dalı (2007-2011)
• Eskisehir Osmangazi Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı. Çocuk Gastroenteroloji ve Hepatoloji Bilim Dalı (2011-2016)
• Eskisehir Osmangazi Üniversitesi Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı. Çocuk Gastroenteroloji ve Hepatoloji Bilim Dalı (2016.-2019)
• Medipol Üniversitesi Medipol Mega Hastanesi Çocuk Gastroenteroloji, Hepatoloji Ve Beslenme (Mart 2019-Ağustos 2019)

1. F Gürakan, M. Eren, N. Koçak, A. Yüce,  H. Özen, İN Saltık- Temizel, H. Demir. Extrahapatic portal vein thrombosis in children: etiology and long term follow-up. J Clin Gastroenterol. 2004; 38: 368-72.
2. Saltik-Temizel IN, Eren M, Demir H, Uslu N, Usta Y, Ozen H, Gürakan F, Yüce A.
Bone mineralization in children with inflammatory bowel disease: what is the role
of zinc ? Turk J Gastroenterol. 2008;19(4):234-8.
3. Dinleyici EC, Eren M, Yargic ZA, Dogan N, Vandenplas Y. Clinical efficacy of
Saccharomyces boulardii and metronidazole compared to metronidazole alone in
children with acute bloody diarrhea caused by amebiasis: a prospective, randomized, open label study. Am J Trop Med Hyg. 2009;80(6):953-5.
4. Eren M, Dinleyici EC, Vandenplas Y. Clinical Efficacy comparison ofSaccharomyces boulardii and yogurt fluid in acute non-bloody diarrhea in children: a randomized, controlled, open label study. Am J Trop Med Hyg. 2010;82(3):488-91.
5. Makbule Eren, Serap Reyhanioglu, Evrim Ciftci, Emine Dundar, Tercan Us, Cagrı Ener Dinleyici, Ozcan Bor. Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection.Journal of Clinical and Analytical Medicine DOI: 10.4328/JCAM.4340
6. Eren M, Çolak Ö, Işıksoy S, Yavuz A.  Effect of H. pylori infection on gastrin, ghrelin, motilin, and gastroesophageal reflux.Turkısh Journal of Gastroenterology 2015:26(5):367-372  
7. Dinleyici EC, Dalgic N, Guven S, et al. Lactobacillus reuteri DSM 17938 shortens acute infectious diarrhea in a pediatric outpatient setting Jornal de Pediatria 2015;91 (4): 392-396  
8. Dinleyici, E.C. Kara A, Dalgic N et al.Saccharomyces boulardii CNCM I-745 reduces the duration of diarrhoea, length of emergency care and hospital stay in children with acute diarrhoea. Beneficial Microbes 2015;6 (4):415-421      
9. Dinleyici Ener Cagri, Dalgic N,  Sirin G et al. EThe effect of a multispecies synbiotic mixture on the duration of diarrhea and length of hospital stay in children with acute diarrhea in Turkey: Single blinded randomized study Europian Journal of Pediatrics 2013;172 (4) :459-464
10.Dinleyici EC, Eren M, Ozen M et al. Effectiveness and safety of Saccharomyces boulardii for acute infectious diarrhea. Expert Opinion on Biological Therapy 2012:12 (4): 395-410 
11.Ener Cagri Dinleyici, Makbule Eren, Nihal Doğan, Serap Reyhanioğlu, Zeynel Abidin Yargic, Yvan Vandenplas. Clinical efficacy of saccharomyces boulardi or metranidazole in sympthomatic children with Blastocystis hominis infection Parasitol Res. 2011; 108(3):541-545.
12.EC Dinleyici, Probage Study Group , Y Vandenplas .Lactobacillus reuteri DSM 17938 effectively reduces the duration of acute diarrhoea in hospitalised children .Acta Paediatrica 2014103 (7), e300-e305   
13.B Dalgic, S Sari, B Basturk, A Ensari, O Egritas, A Bukulmez, Z Baris, Turkish Celiac Study Group.Prevalence of celiac disease in healthy Turkish school childrenThe American journal of gastroenterology 106 (8), 1512-1517 
15.Ener C. Dinleyici, Daniel Martínez-Martínez , Ates Kara, Adem Karbuz , Nazan Dalgic , Ozge Metin6 , Ahmet S. Yazar  , Sirin Guven , Zafer Kurugol  , Ozden Turel  , Mehmet Kucukkoc , Olcay Yasa, Makbule Eren, Metehan Ozen, Jose Manuel Martí  , Carlos P. Garay, Yvan Vandenplas and Andrés Moya. Time series analysis of microbiota in children suffering from acute infectious diarhea and their recovery after treatmant. Orginal research 2018 open acces doi: 10.3389/fmicb.2018.01230
16.Z Kuloglu, A Kansu, S Selbuz, AG Kalayci, G Sahin, CT Kirsaclioglu, .
The Frequency of Lysosomal Acid Lipase Deficiency in Children With Unexplained Liver Disease Journal of pediatric gastroenterology and nutrition 68 (3), 371-376
17.E Simsek, T Simsek, M Eren, E Yilmaz, D Arik, O Cilingir, S Ceylaner,Clinical, Histochemical, and Molecular Study of Three Turkish Siblings Diagnosed with H Syndrome, and Literature Review. Hormone research in paediatrics, 1-10
18.Eren M, Baskin E, Cila A, Ozen S. Mannitol treatment in central nervous
system lupus. Clin Rheumatol. 2001;20(2):160-1.
19.Eren M, Temizel IN. Duodenogastric reflux and Helicobacter pylori infection
in children. Am J Gastroenterol. 2003;98(6):1443-4.
20.Eren M, Saltik-Temizel IN, Yüce A. Complications after outpatient upper GI endoscopy in children: 45-day follow-up. Am J Gastroenterol. 2003;98(12):2810-1.
21.Eren M, Nur Saltik-Temizel I, Koçak N. Serum homocysteine concentrations in
children with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2004;39(2):215-6.
22.IN Saltık- Temizel, N. Uslu, M. Eren. Helicobacter pylori diagnosis in children with liver cirrhosis. Digestive and Liver Disease 2004; 36: 228.
23.Eren M, Gürakan F, Koçak N. Chronic hereditary pancreatitis with N29I mutation
in a Turkish child. Turk J Pediatr. 2005;47(2):173-5.
24.Eren M, Saltik-Temizel IN, Yüce A, Cağlar M, Koçak N. Duodenal appearance of giardiasis in a child with selective immunoglobulin A deficiency. Pediatr Int. 2007;49(3):409-11.
25.Eren M, Eren S, Aydın O, Arıkan S. Varicella-associated colitis in a 6-month-old infant. J Pediatr Gastroenterol Nutr. 2006;43(5):688-90.
26.Eren M, Celik M, Kinik S, Arda IS. A case of Hirschsprung disease: does thyroid hormone have any effect? Turk J Pediatr. 2009;51(1):94-6.
27.Makbule Eren, Mustafa Açıkalın. A case report of Wells’syndrome in a celiac patient. The Turkish Journal of Gastroenterology 2010;21(2):172-4
28.Dinleyici M, Saracoglu N, Eren M,et al.Giant condyloma acuminate due to human papillomavirus type 16 in an infant successfully treated with topical imiquimod therapy
Dermatology Reports 2015; 7(3): 31-33 
29. Zeynep Canan Özdemir , Ayşe Bozkurt Turhan , Makbule Eren , Özcan Bor Is N-acetylcysteine infusion an effective treatment option in L-asparaginase associated hepatotoxicity? Blood Res 2017;52:62-76

1. M.Eren, C. Akyüz, B. Yalçın, A. Varan, T. Kutluk, M. Büyükpamukçu. Çocukluk Çağı Kanserlerinde Kemoterapi ile İlişkili Mukozit Tedavisinde Granülosit Makrofaj Stimülan Faktörün Ağız Bakımındaki Yeri. Uluslar arası Hematoloji Onkoloji Dergisi (International Journal of Hematoloji and Onkoloji). 2007; 17: 70-78.
2. M. Eren, Dinleyici EC, Hekim S.  Third-line Rescue Therapy with Levofloxacin Based Protocol for H. pylori Eradication in Children. J Pediatr Inf 2009;3:98-103.
3. EC Dinleyici, Z Kilic, S Sahin, R Tutuncu-Toker, M Eren, ZA Yargic,  Kosger P,   Ucar B.Heart rate variability in children with tricyclic antidepressant intoxication.Cardiology research and practice 2013:2013 
4. M Eren, SH Yıldırım, IA Sivrikoz. Safety profile of six months lansoprozole treatment in children Indian Journal of Gastroenterology 29 (6), 247-248
5. IN. Saltık- Temizel, M. Eren, H. Demir, N. Koçak. Helicobacter pylori related duodenal ulcer in children. International Pediatrics. 2003; 18: 235.
6. Eren M, Saltik-Temizel IN, Demir H. Esophagogastroduodenoscopy in childhood inflammatory bowel disease. Indian J Gastroenterol. 2003;22(6):236-7.
7. Koçak N, Eren M, Yüce A, Gümrük F. Hemophagocytic syndrome associated with
visceral leishmaniasis. Indian Pediatr. 2004;41(6):605-7.
8. Eren M, Saltik-Temizel IN, Demir H, Koçak N, Ozen H, Gürakan F, Yüce A.
Thrombophilic factors in Turkish children with inflammatory bowel disease. Indian
J Gastroenterol. 2006;25(6):318-9. 
9. Eren M. Peginterferon treatment in children: A Review of chronic Hepatitis B and Hepatitis C treatment. Journal of Pediatric sciences; 2009 1;e4.
10. Arda MS, Tokar B, İlhan H, Eren M. Massive Gastrointestinal Bleeding in Children:
Diagnosis by Enterotomy Introduced Endoscopy J Clin Anal Med 2013;4(suppl 1): 4-6
11. K Harmanci, M Eren, A Kadir Koçak, N Ipar, S Sahin. Elma yağının yanlış kullanımına bağlı gelişen kimyasal pnömonili bir olgu.  Asthma Allergy Immunology/Astim Allerji Immunoloji 2011 (9) 101-104    
12.. Makbule Eren Evolution of Pediatric Gastroenterology Vol 3:4, e97: 2-4 (editorial)

1.    C. Akyüz, M. Eren, K. Çağlar, B. Yalçın, A. Varan, M. T. Kutluk and M. Büyükpamukçu. Effectiveness of rhGM-CSF mouthwashes on Chemotherapy induced mucositis in childhood solid tumors: A randomised clinical trial. International Society of Pediatric Oncology SIOP XXXIV Meeting, September 18-21, 2002, Portugal, Poster No: 383. Medical and Pediatric Oncology  2002: 39; 372. 
2.    Sare Kabukçuoğlu, Tuncay Temel, Ayşegül Harmancı, Makbule Eren, Ertugrul Colak. Intraepithelial lymphocytosis and CD10/NEP Expression of düodenal Mucosa in Iron Deficiency Anemia. 3th International Congress of Pathology. Barcelona. May 17-22, 2008
3.    E.C.Dinleyici,O. Bor,T. Us, K. Arıkbuka, M. Eren,Z.A. Yargic, C.Yarar, B.Yildiz. N. Kasifoglu, N.Tekin. Clinical-Laboratory Fındings and Prognosis of Ganciclovir- Treated Infants With Cytomegalovirus Infection:A Single Center Experience. 27th Annual Meeting of The European Society For Pediatric Infectious Diseases Journal. June 9-13, 2009, Belgıum. e215.Poster No:686
4.    Eren M, Ucar B, Urhan B, ozkan R, Açıkalın M, Kılıc Z.Pulmonary Veno-Oclussive Disease in a Child with Prothrombine Gene Mutation 5th World Congress of Paediatric Cardiology and Cardiac Surgery.21-26 June 2009. Cairns, Australia, PN:8121. Cardiology in the Young, Volume 20, Supplement S1, 2010, pp 1-422.
5.    Eren M, Dinleyici EC, Vandenplas Y. Clinical Efficacy Comparision of Saccharomyces Boulardai And Yoghurt Fluıd in Acute Non-Bloody Diarrhea in Children: A Randomized, Controlled open lable study. 5th  Probiotics, Prebiotics and New Foods meeting.September 13-15, 2009 Rome.
6.    Eren M, Hekim S, Sivrikoz  I.The Impact Of Long Term Lansoprozole Treatment On Serum Iron, Calcıum, Vıtamın B12, Bone Turnover And Communıty Acquıred Pneumonıa In Chıldren. JPGN 2010;50 (Suplement 2) E132-E133
7.    E.Dinleyici, M. Eren, N. Dogan, S.Reyhanioglu, A Yargic, Y. Vandenplas. A singel blinded study on clinical Efficacy of saccharomyces Boulardi or Metranidazole in Sympthomatic Children with Blastocystis Homınıs Infection. 43. annual meeting of europian Sociaty of pediatric gastroenterology, Hepatology and Nutrition, Istanbul. Published in JPGN volum 50, suppl 2, p93, june 2010  
8.    E.C. Dinleyici, M. Eren, Z.A.Yargic, Y. Vandenplas. Cost Effectiveness of add-on-Probiotics (Saccharomyces boulardi) in children with acute rota virus diarhea in Turkey (sb-Costr). 44 th Annual Meeting of Europian Society Of pediatric gastroenterology, Hepatology and Nutrition. 25-28 May 2011 sorento,Italy
9.    E.C.Dinleyici, N Dagıc, S. Guven, O.M. Tımur, M.Eren, M.Ozen, A.Kara, G.Tanır,V.Arıca, M.Sancar, E.Temur, O.Turel, Z.Kurugöl, G.Akca, O.Yasa, M.Ergüven, Y.Vandenplas .The effect of Lactobacillus reuteri on the duration of Diarrhea and Length of Hospital stay in children with acute Diarrhea in Turkey: Prospective,single blind,randomised controlled trial. 46. Annual Meeting Of Europian Pediatric Gastroenterology, Hepatology And Nutrition8-11 May 2013 PD-G-0091
10.    Makbule Eren, Ömer Colak,Serap Isıksoy, Aslı Yavuz. The Effect of H. Pylori Eradication on Some Gastric Hormones, Enzymes and Gastroesophagial reflux Disease.4th World Congress of Pediatric Gastroenterology, Hepatology and Nutrition 2012 Taiwan PP21007
11.    Enver Şimşek, Makbule Eren, Meliha Demiral, Çiğdem Binay,Tülay Şimşek,Baran Tokar.Neurofibromatosis Type 1 presenting with secondery amenorrhea and Wastingsyndrome.Endocrin Society 97th Annual meeting and Expo. March 5-8 2015, San Diego.
12.    Dinleyici EC, Kurugol Z, Dalgic N, Yasa O, Guven S, Nalbantoglu B, Karbuz A, Arica V, Silfeler I, Bulut S, Yazar AS, Metin O, Tanir G, Turel O, Sancar M, Eren M, Ozen M, Kara A, Vandenplas Y. The effects of Bifidobacterium lactis, Bifidobacterium lactis plus inulin, inulin and placebo on the duration of diarrhea in children: a randomised, multi-center, double blind, placebo controlled clinical trial. ESPGHAN 48th Annual Meeting of the Euroepan Society for Paediatric Gastroenterology Hepatology and Nutrition, 6-9 May 2015, Amsterdam, PO-G-0180. published in JPGN 2015:60: suplement 1
13.    Dinleyici EC, Kurugol Z, Dalgic N, Yasa O, Guven S, Nalbantoglu B, Karbuz A, Arica V, Silfeler I, Bulut S, Yazar AS, Metin O, Tanir G, Turel O, Sancar M, Eren M, Ozen M, Kara A, Vandenplas Y.Cost effective anaylsis of Add-On Saccharomyces Boulardii CNCM I-745 ın children with acute infectious Diarhea In Turkey (PROBAGE Study) 48 th Annual Meeting of ESPGHAN Amsterdam.PG 0183 published in  JPGN 2015;60 suplement 1
14.    Kilic Yıldırım Gonca,Durmuş Aydoğdu S, Eren M, Tekin T. Abetalipoproteinemia: Case Report. .J Inherited Metab Dis.2015 (38), (Suppl 1).S-35: A-060
15.    Makbule Eren, Yalcın Kara,Serap Arslan, Oguz Cilingir. IL-15 gene polymorphism in celiac disease patient and their healthy siblings.49th ESPGHAN Annual meeting 25-28 May 2016-Atina
16.    Makbule Eren, Birgül Kırel, Tuna Tekin, Yalcin Kara the effect of vitamin D Deficiency on non alcoholic Fatty liver disease development in obese children. 49th ESPGHAN Annual meeting 25-28 May 2016-Atina (Yayınlandığı dergi:JPGN 2016:62:616 suplement:1
17.    Fecal microbiota analysis in children receiving saccharomyces boulardii cncm i-745 due to acute rotaviral infectious diarrhea (facid study): a new mechanism of action for probiotics
Ener Cagri Dinleyici, Daniel Martine, Ates Kara, Andres Moya, Adem Karbu, Nazan Dalgic, Ozge Metin, Ahmet Sami Yazar, Sirin Guven, Zafer Kurugol, Ozden Turel, Mehmet Kucukkoc, Olcay Yasa, Makbule Eren, Metehan Ozen, Yvan Vandenplas,world congress of Pediatric Gastroenterology, Hepatology and Nutrition ekim 5-8, Montreal, Kanada. Yayınlandığı yer: JPGN;2016: (63):267, supplement 2.
18.    Ener Cagri Dinleyici, Ates Kara, Metehan Özen, Nazan Dalgic, Sirin Guven, Zafer Kurugol,
Ozge Metin Akcan, Olcay Yasa, Adem Karbuz, Ahmet Sami Yazar, Ozden Turel,
Burcin Nalbantoglu, Vefik Arica, Ibrahim Silfeler, Gonul Tanir, Mesut Sancar, Makbule Eren, Yvan Vandenplas. PROBAGE Study: Final report of the largest clinical trial with probiotic/synbiotics in children with acute infectious gastroenteritis in Turkey JPGN 2017;64:429 supplement1 
19.    Funda Ozgenc, Zarife Kuloğlu, Nafiye Urganci, Tulay Erkan, Zerrin Onal, Sinan Sarı, Turkish Pediatric IBD Study Group Pediatric inflammatory bowel diseases in Turkey: results of Turkish pediatric IBD Database. JPGN 2017;64:527 supplement 1
20.    Zarife Kuloglu, Aydan Kansu Tanca1, Suna Selbuz. Ayhai GaziKalaycı, Gülselen şahin,Ceyda Tuna Karsacıoğlu, Kaan Derirören, Buket Dalgıç, Erhun Kasırga. Zerrin Önal, Ali İşlek.National LAL_D study Glotp The lrequency of lysosomalacid lipase deficiency in children with unexplainedtran§aminase elevation and chroni6lıver disease in Turkey
21.    Infantile systemic hyalinosis presenting with intestinal lymphangiectasia Yusuf Aydemir1, Makbule Eren1, Coskun Yarar1, Omer Kilic1, Koray Harmancı. JPGN Vol. 66, Supplement 2, April 2018 308

• Milli Pediatri Derneği
• Türk Pediatri Kurumu
• Çocuk Gastroenteroloji, Hepatoloji ve Beslenme Derneği
• Ulusal Gastroenteroloji Derneği
• Klinik Enteral Parenteral Nutrisyon Derneği (KEPAN)
• European Society of Clinical Nutrition and Metabolism, (ESPEN)
• Europian Society of Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN)
• Pediatrik Prebiyotik ve Probiyotik Derneği
• Türk Karaciğer Araştırmaları Derneği

• “Correlation of Liver Enzymes and Liver Histology in Chronic Hepatitis B Virus Infection” başlıklı Makale ile .Journal of Clinical and Analytical Medicine dergisi tarafından 2016 yılı éYusuf Peker Best Article Award” ödülüne layık görülmüştür.