Recurrent Pregnancy Losses are Preventable
Article Content
When to examine pregnancy losses?
What are the causes?
What procedures are used?
Miscarriage before 20 weeks is evaluated as pregnancy loss. Stating that 10-15% of clinically detected pregnancy result miscarriage, Liv Hospital Obstetrician and Perinatology Specialist Prof. Dr. Arda Lembet said “Genetic factors (abnormal count or structure of embryo chromosomes) are responsible for 50-75% of pregnancy losses. 1% of fertile women suffer from 3 or more miscarriages and these cases are called recurrent pregnancy loss”. Spec. MD. Hafsa Uçur explained the causes of pregnancy losses and gave a roadmap for prevention.
• If heartbeat is detected in the embryo and especially in case of miscarriage during second trimester
• If normal karyotype analysis has been reported in genetic examination collected from previous pregnancy loss
• Mother older than 35
• Mother with infertility
• Abnormality in karyotype (genetic) analysis of mother and/or father
Although recurrent pregnancy loss is defined as 3 or more miscarriages, two consecutive pregnancy losses or miscarriages in second trimester are enough to initiate diagnostic investigation.
• Anatomic factors
• Congenital (uterus septum, unicornuate uterus, uterine didelphys, bicornuate uterus) or acquired abnormalities (myoma, intrauterine adhesions) in the mother's uterus
• Immune system-related factors (systemic lupus erythematosus, antiphospholipid syndrome)
• Congenital thrombophilias (coagulation disorders), placenta pathologies
Karyotype analysis for mother and father candidates (genetic analysis with collected blood samples), 4D ultrasonography, hysterosalpingography (imaging uterine and tubes with drug administration), hysteroscopy, laparoscopy to examine any potential anatomic problems in the uterine of mother. For the examination of congenital or acquired thrombophilias (coagulation disorders) and immunological disorder, comprehensive thrombophilia tests including different assays such as thrombophilia panel study, genetic mutations and lipoprotein A can be performed on blood samples collected from mother candidates. In women who get pregnant after recurrent pregnancy loss, chromosome analysis for pregnancy can provide valuable information with interventional procedures in mother’s womb, such as amniocentesis, chorionic villus sampling and cordocentesis.
When to examine pregnancy losses?
• If heartbeat is detected in the embryo and especially in case of miscarriage during second trimester• If normal karyotype analysis has been reported in genetic examination collected from previous pregnancy loss
• Mother older than 35
• Mother with infertility
• Abnormality in karyotype (genetic) analysis of mother and/or father
Although recurrent pregnancy loss is defined as 3 or more miscarriages, two consecutive pregnancy losses or miscarriages in second trimester are enough to initiate diagnostic investigation.
What are the causes?
• Anatomic factors• Congenital (uterus septum, unicornuate uterus, uterine didelphys, bicornuate uterus) or acquired abnormalities (myoma, intrauterine adhesions) in the mother's uterus
• Immune system-related factors (systemic lupus erythematosus, antiphospholipid syndrome)
• Congenital thrombophilias (coagulation disorders), placenta pathologies
What procedures are used?
Karyotype analysis for mother and father candidates (genetic analysis with collected blood samples), 4D ultrasonography, hysterosalpingography (imaging uterine and tubes with drug administration), hysteroscopy, laparoscopy to examine any potential anatomic problems in the uterine of mother. For the examination of congenital or acquired thrombophilias (coagulation disorders) and immunological disorder, comprehensive thrombophilia tests including different assays such as thrombophilia panel study, genetic mutations and lipoprotein A can be performed on blood samples collected from mother candidates. In women who get pregnant after recurrent pregnancy loss, chromosome analysis for pregnancy can provide valuable information with interventional procedures in mother’s womb, such as amniocentesis, chorionic villus sampling and cordocentesis.
* Liv Hospital Editorial Board has contributed to the publication of this content .
* Contents of this page is for informational purposes only. Please consult your doctor for diagnosis and treatment. The content of this page does not include information on medicinal health care at Liv Hospital .
* Contents of this page is for informational purposes only. Please consult your doctor for diagnosis and treatment. The content of this page does not include information on medicinal health care at Liv Hospital .
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28 May 2024 10:25:50
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